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Natural Fe isotope fractionation in an intestinal Caco-2 cell line model
In this work, Fe isotopic analysis of samples obtained from an in vitro intestinal model was performed via multi-collector ICP-mass spectrometry (MC-ICP-MS) to evaluate the isotope fractionation accompanying Fe uptake and transport mechanisms at a cellular level.
Good experimental repeatability and reproducibility were attained with low blank contribution levels, allowing precise and reliable Fe isotope ratio results.
After 24 hours of exposure, the trend observed was towards a light Fe isotopic composition in the cells, whereas the apical solutions were enriched in the heavier isotopes.
An overall increase in delta Fe values of the cell layers exposed to Fe treatment relative to the corresponding values for the untreated cells also seems to support the assumption of a preferential accumulation of heavy isotopes in enterocyte ferritin.
The consistency of the results obtained supports the usefulness of in vitro cell culture models as an interesting complementary tool for studying Fe metabolic pathways at the intestinal level.
Anthocyanin Absorption and Metabolism by Human Intestinal Caco ...
One of the key factors affecting the bioavailability of anthocyanins is their transport through the gut epithelium.
The Caco-2 cell line, a human intestinal epithelial cell model derived from a colon carcinoma, has been proven to be a good alternative to animal studies for predicting intestinal absorption of anthocyanins.
Studies investigating anthocyanin absorption by Caco-2 cells report very low absorption of these compounds.
However, the bioavailability of anthocyanins may be underestimated since the metabolites formed in the course of digestion could be responsible for the health benefits associated with anthocyanins.
In this review, we critically discuss recent findings reported on the anthocyanin absorption and metabolism by human intestinal Caco-2 cells.
Phys. Rev. Lett. 119, 147201 (2017) - Effective One-Dimensional ...
(a),(c) LO and (b),(d) TR cuts of data through (0.55, 0.55) at (a),(b) 52.5–57.5 and (c),(d) 42.5–47.5 meV.
TR cuts were averaged from 0.3–0.8 r.l.u. in the LO direction and LO cuts in the TR directions.
Both data are corrected for the magnetic form factor after subtracting a background contribution estimated from Gaussian fits to the TR cuts.
The green lines in the TR cuts are fits to a Gaussian line shape and blue solid lines are fits to the diffusive model.
(e) Energy dependence of the imaginary part of the dynamical susceptibility centered at (0.55, 0.55) and averaged along the LO direction from 0.3–0.8 r.l.u. Each data point is obtained after fitting the TR cuts with a Gaussian line shape.
The Caco-2 cell monolayer: usefulness and limitations.
The Caco-2 monolayer has been used extensively for the high-throughput screening of drug permeability and identification of substrates, inhibitors, and inducers of intestinal transporters, especially P-glycoprotein (P-gp).
Traditionally, the Caco-2 monolayer is viewed as a single barrier rather than a polarized cell monolayer consisting of metabolic enzymes that are sandwiched between two membrane barriers with distinctly different transporters.
This review addressed the usefulness and limitations of the Caco-2 cell monolayer in drug discovery and mechanistic studies.
This mini-review covered applications of the Caco-2 monolayer, clarified misconceptions, and critically addressed issues on data interpretation.
The catenary model extends the usefulness of Caco-2 monolayer and provides proper mechanistic insight and data interpretation.
Anthocyanin Absorption and Metabolism by Human Intestinal Caco ...
One of the key factors affecting the bioavailability of anthocyanins is their transport through the gut epithelium.
The Caco-2 cell line, a human intestinal epithelial cell model derived from a colon carcinoma, has been proven to be a good alternative to animal studies for predicting intestinal absorption of anthocyanins.
Studies investigating anthocyanin absorption by Caco-2 cells report very low absorption of these compounds.
However, the bioavailability of anthocyanins may be underestimated since the metabolites formed in the course of digestion could be responsible for the health benefits associated with anthocyanins.
In this review, we critically discuss recent findings reported on the anthocyanin absorption and metabolism by human intestinal Caco-2 cells.